GELCLAIR® has a mechanical action indicated for the management of pain and relief of pain by adhering to the mucosal surface of the mouth, soothing oral lesions of various etiologies, including oral mucositis/stomatitis. It is a concentrated oral gel available in single use packets of 15 ml each.
GELCLAIR® bioadherent oral gel helps patients who are undergoing radiation or chemotherapy (or a combination of the two) by relieving the pain of oral mucositis. GELCLAIR® is composed of three key ingredients that combine to provide pain relief to the mucosal surface of the mouth:
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Polyvinylpyrrolidone (PVP) protects the mucosa
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Hyaluronic acid (sodium hyaluronate) hydrates and soothes the mucosa
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Glycyrrhetinic acid (licorice root extract) is a mild flavoring agent gentle on the mucosa
GELCLAIR® is designed to be
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Non-numbing
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Non-stinging
- Non-drying
Adapted from Cawley
GELCLAIR® coats the exposed nerve endings of the mucosa throughout the phases of oral mucositis
GELCLAIR® provides rapid and durable pain relief. Study results show that GELCLAIR® significantly reduces oral mucositis pain for 5 to 7 hours after administration.11
Short-Term results
In an open label study 30 patients experienced a 92% reduction in mean overall oral pain associated with lesions of the mouth and oropharyx 5 to 7 hours after treatment (p<0.005)11,12
Open-label study of 30 patients with painful lesions of the mouth and oropharynx associated with chemotherapy, radiation, mucositis, HIV disease, severe diffuse aphthous ulcers, or oral surgery. Pain was scored on a Visual Numerical Scale ranging from 0 (no pain) to 10 (worst pain), with scores recorded at baseline and at 5 to 7 hours after treatment. GELCLAIR® was administered TID.11
GELCLAIR® helps patients restore the ability to eat and drink more normally.11,12
Medium-term results
in the same open label study 87% of patients reported reduced pain associated with swallowing foods, liquids, and saliva after 7 days of use (p<0.005)11,12
GELCLAIR® helped reduce pain associated with eating and drinking.11,12
Safety Profile
GELCLAIR® has a favorable safety profile:10
No adverse events have been reported in clinical trials with the use of GELCLAIR®. Postmarketing reports have included infrequent complaints of a burning sensation in the mouth.
